{"created":"2023-06-21T07:19:09.935197+00:00","id":977,"links":{},"metadata":{"_buckets":{"deposit":"4b34a068-5a25-4afb-92b5-0fa547d435f9"},"_deposit":{"created_by":3,"id":"977","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"977"},"status":"published"},"_oai":{"id":"oai:tbgu.repo.nii.ac.jp:00000977","sets":["1:3:24:29:219"]},"author_link":["1820","1823"],"control_number":"977","item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"17","bibliographicPageStart":"3","bibliographicVolumeNumber":"16","bibliographic_titles":[{"bibliographic_title":"東北文化学園大学医療福祉学部リハビリテーション学科紀要 : リハビリテーション科学"},{"bibliographic_title":"Rehabilitation science : memoirs of the Tohoku Bunka Gakuen University Faculty of Medical Science & Welfare, Department of Rehabilitation","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"卵巣からのエストロゲンは視床下部-下垂体-性腺系を介して性成長や性周期に重要な役割を果たす一方,閉経後のエストロゲンの低下は骨粗鬆症などの骨代謝ばかりでなく,心筋や骨格筋にも影響を及ぼす。エネルギー産生に必須な母系遺伝のミトコンドリアは,骨格筋ばかりでなく心筋や平滑筋に豊富に含まれる。ミトコンドリアはエストロゲン受容体を持ち,エネルギー産生以外にも様々な代謝にエストロゲンの影響を受けている。近年,胃がエストロゲンを合成し,その門脈への分泌量は卵巣の発情前期に匹敵するほど多いことが明らかとなった。雌雄を問わず体循環中のエストロゲン値は摂食活動と肝機能に深く関係しており,様々な生理的や病理学的条件での体循環中エストロゲン値の変化を知ることは,筋骨格系を扱う理学療法学分野で重要と考えられる。現在まで研究されてきた胃エストロゲンの全体像をここに紹介する。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Estrogen is major hormonal regulator of bone and muscle metabolism in women and men. There is, therefore, considerable interest in unraveling pathways on which estrogen exerts protective effect on bone and skeletal muscle. The major consequence of the loss and deficiency of estrogen is an increase in bone absorption to cause osteoporosis or osteopenia. The heart and skeletal muscle is rich in mitochondria in their cytoplasm, and the function of mitochondria is regulated by estrogen mediated its receptors. Mitochondria are maternally inherited and unique organelles involving in the supply of energy to the host cell, in multiple biochemical processes of calcium homeostasis, regulation of reactive oxygen species, pH control, cell death, and so on. Decades years ago Ueyama et al. (2002) reported that parietal cells in gastric mucosae synthesize and secrete high amount of estrogen into portal vein to keep hepatic functions in rats. The phenomena occur in various kinds of animals including human. During the development of rats, gastric estrogen synthesis and secretion start at weaning, and then increase rapidly to their maturation. The synthesis and secretion of gastric estrogen make a circadian rhythm but not circalunar rhythm observed in ovary. The circadian rhythm is correlated to food intake. Estrogen level in the portal vein is several times higher than that in the systemic circulation, because a large amount of gastric estrogen is bound to hepatic estrogen receptors to keep the liver functions. A part of gastric estrogen passed through the liver flows into systemic circulation, and then acts on the peripheral organs including bone and muscle. Here we show the recent data and reports on the gastric estrogen and its systemic circulation in various physiological and pathological conditions of animals, and we discuss the importance of gastric estrogen on the bone and muscle function.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東北文化学園大学医療福祉学部リハビリテーション学科"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12032779","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13497197","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"白澤, 信行","creatorNameLang":"ja"},{"creatorName":"シラサワ, ノブユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小林, 裕人","creatorNameLang":"ja"},{"creatorName":"コバヤシ, ヒロト","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-04-21"}],"displaytype":"simple","filename":"03.pdf","filesize":[{"value":"3.9 MB"}],"format":"application/pdf","licensetype":"license_8","mimetype":"application/pdf","url":{"label":"第16巻第1号　03","url":"https://tbgu.repo.nii.ac.jp/record/977/files/03.pdf"},"version_id":"e4bc8c42-6c95-4672-9000-b38879aab3b7"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"胃のエストロゲンが骨と筋に及ぼす影響について : 理学療法を行う上で考慮すべき食事指導の重要性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"胃のエストロゲンが骨と筋に及ぼす影響について : 理学療法を行う上で考慮すべき食事指導の重要性","subitem_title_language":"ja"},{"subitem_title":"Effects of gastric estrogen on the bone and muscle formation : Dietary intake is an important knowledge for　physical therapists","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"3","path":["219"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-04-21"},"publish_date":"2020-04-21","publish_status":"0","recid":"977","relation_version_is_last":true,"title":["胃のエストロゲンが骨と筋に及ぼす影響について : 理学療法を行う上で考慮すべき食事指導の重要性"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-12-01T04:35:36.046731+00:00"}